Articles in Category: More News

Pegylated Substances from 4 to 60 kDa in plasma, CSF and formulation

News from Wednesday, 11 July 2018.

Pegylated Substances from 4 to 60 kDa in plasma, CSF and formulation

pharm-analyt − Leading Lab in PEG Analysis

After having completed another method establishment for a Polyethylenglycol (PEG) recently, pharm-analyt continues to be a leading lab in PEG analysis. Quantitative analysis has always been the main pillar for pharm-analyt for over
3 decades of operation.

Starting in 1986 with bioanalysis and HPLC-UV nowadays GMP release analysis and HPLC-MS/MS are at the core of pharm-analyt's activities. With only 20 people being employed at pharm-analyt we have kept our flexibility in order to solve analytical challenges and more recently also consistently keep timelines.

Quantifying PEGylated substances has been a specialty for more than a decade becoming a core competence in the last 2 years. At the moment pharm-analyt serves 4 different clients with quantitative analysis of PEGs and has methods to determine altogether 6 current pegylated substances in the range of 4 to 60 kDa.

pharm-analyt has covered PEG determination in the biological matrices rat/human plasma/CSF and FDP/FC/BDS formulations, always going in the direction of using stable labelled internal standards.

The most refined and up-to-date method has a calibration range of 20 to 1,000 ng/mL for a more than 50 kDa PEG in plasma with a calibration curve that is linear.

We are good at analysing various peptides, mycotoxins and anthracyclines which makes us a valued provider for the pharmaceutical industry especially in oncology/chemotherapy. However, amazement you would only experience with the PEG analytical competence and metaknowledge you will find at pharm-analyt.

Send us your quantitative analytical problem with a PEG over, you will have a 95 % chance that we will have a solution within short time.

 

> 50 kDa Free PEG in Plasma
Calibration range 20.0 – 1,000 ng/mL
Upper chrom Std at LLOQ
Lower chrom internal standard
HPLC-MS/MS

Meet our Founder @ Rare 2018 in London

News from Wednesday, 21 March 2018.

Meet our Founder @ Rare 2018 in London

Meet our Founder @ Rare 2018 in London

Meet our Founder at Rare 2018 in London!

Hermann is well known in the community, as he found several biomarkers for rare lysosomal diseases e.g. Fabry, Gaucher, NP-C, MLD.

Meet our new head of Business Development@BIO-EUROPE in Berlin!

News from Thursday, 12 October 2017.

Meet our new head of Business Development@BIO-EUROPE in Berlin!

Meet our new head of Business Development@BIO-EUROPE in Berlin!

Meet our new head of Business Development@BIO-EUROPE in Berlin!

Reinhard received a PhD in Clinical Pharmacology from the University of Vienna (thesis about development of a multi compound HPLC method with semi-automated SPE). He has a long time experience in selling chromatography disposables, instruments and services within Europe.

His goal as the head of business development at pharm-analyt is to work closely with clients for a better understanding for the future needs in the market.

Bioanalytical Winter Promotion

News from Monday, 21 November 2016.

Bioanalytical Winter Promotion

Bioanalytical Winter Promotion

It has been quite a hot period for us between summer 2015 and summer 2016 here at pharm-analyt. Due to capacity improvements in documentation we have been able to close many projects by fall 2016. The winter season appears to be cooler, for us also in terms of business, and we are anticipating excess capacity between December 2016 and February 2017.

However, we are not even considering hibernating!

Rather, we invite you to join our seasonal promotion: If you order one of the two packages gingerbread or mistletoe between 1 December 2016 and 28 February 2017 you will benefit from our promotional package prices. The GLP assays qualifying for the packages are displayed in a table below:

 

 

 

 

List of GLP Assays Eligible for Bioanalytical Winter Promotion

Allopurinol and Oxipurinol Human Plasma 0.1 mL 2 - 500 ng/mL both
Azelaic Acid Human Plasma 0.05 mL 1 - 500 ng/mL
Budesonide Human Plasma 0.25 mL 5 - 1000 pg/mL
Cortisol Human Plasma 0.1 mL 1.5 - 500 ng/mL
Cortisol Human Serum 0.1 mL 1.5 - 500 ng/mL
Cortisol Human Urine 0.1 mL 1.5 - 500 ng/mL
Cyclosporin A Whole Blood 0.05 mL 0.2 - 100 ng/mL
Esmolol Whole Blood 0.05 mL 10 - 5000 ng/mL
Fluticasone Propionate Human Plasma 1 mL 0.25 - 50 pg/mL
Fluticasone Propionate Human Serum 0.25 mL 3 - 1000 pg/mL
Formoterol Human Plasma 0.25 mL 0.4 - 100 pg/mL
Landiolol Whole Blood 0.05 mL 10 - 5000 ng/mL
Metformin Human Plasma 0.05 mL 10 - 2000 ng/mL
Nabilone Human Plasma 0.5 mL 0.05 - 10 ng/mL
n-Acetyl-Carnitine Human Plasma 0.02 mL 50 - 10000 ng/mL
Nicorandil Human Plasma 0.1 mL 1 - 500 ng/mL
Paclitaxel Human Plasma 0.05 mL 8 - 8000 ng/mL
Pimelic Acid Human Plasma 0.05 mL 0.5 - 250 ng/mL
Raloxifene Human Plasma 0.5 mL 20 - 5000 pg/mL
Salmeterol Human Serum 0.25 mL 2 - 600 pg/mL
Treprostinil Human Plasma 0.25 mL 4 - 2000 pg/mL

 
Note: This is only a small fraction of pharm-analyt's assays