Meet pharm-analyt at the following conferences:
14.00 Derivatisierungsfreier Nachweis von Östrogenen in Plasma im untersten pg/ml Bereich mittels Ionen Mobilität auf einem High-End-QTRAP System, Prof. Hermann Mascher
Articles in Category: More News
Bioanalytical Winter Promotion
Bioanalytical Winter Promotion
It has been quite a hot period for us between summer 2015 and summer 2016 here at pharm-analyt. Due to capacity improvements in documentation we have been able to close many projects by fall 2016. The winter season appears to be cooler, for us also in terms of business, and we are anticipating excess capacity between December 2016 and February 2017.
However, we are not even considering hibernating!
Rather, we invite you to join our seasonal promotion: If you order one of the two packages gingerbread or mistletoe between 1 December 2016 and 28 February 2017 you will benefit from our promotional package prices. The GLP assays qualifying for the packages are displayed in a table below:
List of GLP Assays Eligible for Bioanalytical Winter Promotion
| Allopurinol and Oxipurinol | Human Plasma | 0.1 mL | 2 - 500 ng/mL both |
| Azelaic Acid | Human Plasma | 0.05 mL | 1 - 500 ng/mL |
| Budesonide | Human Plasma | 0.25 mL | 5 - 1000 pg/mL |
| Cortisol | Human Plasma | 0.1 mL | 1.5 - 500 ng/mL |
| Cortisol | Human Serum | 0.1 mL | 1.5 - 500 ng/mL |
| Cortisol | Human Urine | 0.1 mL | 1.5 - 500 ng/mL |
| Cyclosporin A | Whole Blood | 0.05 mL | 0.2 - 100 ng/mL |
| Esmolol | Whole Blood | 0.05 mL | 10 - 5000 ng/mL |
| Fluticasone Propionate | Human Plasma | 1 mL | 0.25 - 50 pg/mL |
| Fluticasone Propionate | Human Serum | 0.25 mL | 3 - 1000 pg/mL |
| Formoterol | Human Plasma | 0.25 mL | 0.4 - 100 pg/mL |
| Landiolol | Whole Blood | 0.05 mL | 10 - 5000 ng/mL |
| Metformin | Human Plasma | 0.05 mL | 10 - 2000 ng/mL |
| Nabilone | Human Plasma | 0.5 mL | 0.05 - 10 ng/mL |
| n-Acetyl-Carnitine | Human Plasma | 0.02 mL | 50 - 10000 ng/mL |
| Nicorandil | Human Plasma | 0.1 mL | 1 - 500 ng/mL |
| Paclitaxel | Human Plasma | 0.05 mL | 8 - 8000 ng/mL |
| Pimelic Acid | Human Plasma | 0.05 mL | 0.5 - 250 ng/mL |
| Raloxifene | Human Plasma | 0.5 mL | 20 - 5000 pg/mL |
| Salmeterol | Human Serum | 0.25 mL | 2 - 600 pg/mL |
| Treprostinil | Human Plasma | 0.25 mL | 4 - 2000 pg/mL |
Note: This is only a small fraction of pharm-analyt's assays
Reflection on Three Decades of Bioanalysis
Reflection on Three Decades of Bioanalysis
Reflection on Three Decades of Bioanalysis
As founder and CEO of pharm-analyt I go back a long way.
Back in 1975, when I started in the field of bioanalysis, HPLC was brand new technology and UV detectors with fixed wavelength at 254 nm were just becoming the new standard.
In 1978 I obtained a “SP8000”. Being the “Mercedes” among the HPLC-systems, it featured a ternary gradient(!) and a Schoeffel UV detector with variable wavelength! Coming from GC-technology, it was inconceivable, that most any molecule could be determined – not only evaporable molecules or ones made evaporable through derivatisation. Back then, any new molecule determined in plasma was a little sensation, worth a publication!
In the 1990s HPLC-MS systems with ESI (Electrospray Ionisation) and APCI (Atmospheric Pressure Chemical Ionization) became stable enough to be an option for routine work. This is presuming you had the budget, as the cost of technology was outrageously.
I remember, cleaning and establishing “good vacuum” consumed almost half of our time but at least molecules without chromophores and functional groups for derivatisation (e.g. for fluorescence) now became visible in the low ng/mL range.
In the 1980s, a combination of HPLC with electrochemical detectors and glassy carbon, later with porous graphite, was a brilliant option for molecules that can be oxidised.
Then came mass spec technology. The speed of development of HPLC-MS/MS technology since 1995 is staggering! Analyzing peptides with MS has become routine, not to forget PEGylated drugs, hormones and other formerly “terrible” things!
Of course, the femtogram/mL mark in plasma has been passed a long time ago, and we’re ever continuing to shift the limits!
Being part of this dynamic and innovative world of bioanalysis is such a privilege and we are certainly looking forward to the future!
Join us into a new and exciting decade!
Hermann Mascher
CEO and founder of pharm-analyt
ANALYSIS OF DRUGS IN CEREBRAL MICRODIALYSATES
pharm-analyt have recently joined forces with RenaSci (Nottingham) to offer a new service – measurement of drugs and neurotransmitters in the same microdialysate sample.
RenaSci employs dual-probe microdialysis to measure extracellular levels of neurotransmitter in different brain regions of freely-moving rats.
For example, they have recently measured the effects of d-amphetamine 0.5 mg/kg sc on dopamine levels in the nucleus accumbens and on acetylcholine levels in the prefrontal cortex. Microdialysate samples from this study were sent to pharm-analyt for analysis.
The results show an excellent correlation between d-amphetamine concentrations and dopamine levels in the nucleus accumbens and a weaker though still strong relationship between d-amphetamine concentrations and acetylcholine levels in the prefrontal cortex.
pharm-analyt is a fully-independent bioanalytical company based in Baden/Vienna. The company has been measuring small molecules and their metabolites in a variety of biological fluids and tissues for 30 years. For this purpose, they employ state-of-the-art instrumentation mass spectrometry technology. This enables them to quantify drug concentrations in minimal sample volumes with very high sensitivity.
Please click link below to see the data.
The ability to measure drug concentrations and neurotransmitter levels in the same microdialysate sample provides important information regarding the pharmacodynamic-pharmacokinetic properties of the drug.
For further information about this new service please contact us on This email address is being protected from spambots. You need JavaScript enabled to view it. or This email address is being protected from spambots. You need JavaScript enabled to view it.
Certificate of Honor to CEO of pharm-analyt
Certificate of Honor to CEO of pharm-analyt
We announce with pride that our CEO, Prof. Hermann Mascher received yet another award: The Certificate of Honor of the Austrian Society of Chemistry.
The certificate recognizes the implementation of his profound chemical knowledge in scientifically sound and technically mature practice. Moreover, he is honored for meeting the international market´s high demands from a business point of view. Last, but not least, he is recognized for his commitment to the concerns of society as well as his employees.
