pharm-analyt have recently joined forces with RenaSci (Nottingham) to offer a new service – measurement of drugs and neurotransmitters in the same microdialysate sample.
RenaSci employs dual-probe microdialysis to measure extracellular levels of neurotransmitter in different brain regions of freely-moving rats.
For example, they have recently measured the effects of d-amphetamine 0.5 mg/kg sc on dopamine levels in the nucleus accumbens and on acetylcholine levels in the prefrontal cortex. Microdialysate samples from this study were sent to pharm-analyt for analysis.
The results show an excellent correlation between d-amphetamine concentrations and dopamine levels in the nucleus accumbens and a weaker though still strong relationship between d-amphetamine concentrations and acetylcholine levels in the prefrontal cortex.
pharm-analyt is a fully-independent bioanalytical company based in Baden/Vienna. The company has been measuring small molecules and their metabolites in a variety of biological fluids and tissues for 30 years. For this purpose, they employ state-of-the-art instrumentation mass spectrometry technology. This enables them to quantify drug concentrations in minimal sample volumes with very high sensitivity.
Please click link below to see the data.
The ability to measure drug concentrations and neurotransmitter levels in the same microdialysate sample provides important information regarding the pharmacodynamic-pharmacokinetic properties of the drug.